In Lexus claim that they invented the hybrid RX400h luxury to have in 2005 and returned to Los Angeles ten years after the introduction of the RX line to reinvent the industry with everything new in the luxury sport utility vehicles (SUV) RX350 and RX450h 2010.

2010 Lexus RX450h hybrid is powered by a V-6 Atkinson cycle 3.5-liter and the hybrid system is a new and more powerful converter that progresses to a total power of 297 horsepower, 27 horsepower more than the outgoing model. The 275-horsepower gasoline engine comes with 22 additional horsepower generated by the electric motor. Besides the power boost, it has also increased the fuel mileage by 8%, but did not provide specific figures. Using as base the average of 25 mpg (11 km / l) calculated by the Environmental Protection Agency (EPA) of the United States for the outgoing RX400h, the RX450h 2010 must pay on average about 27 mpg (11.5 km / l). The RX450h will be available in the system of 2-wheel drive (2WD) and total drive system (AWD) part-time, with the total traction system consumes a bit more fuel.

The RX350 has the same 2010 V-6 engine from 3.5 liters to double its hybrid without the hybrid drive system. Both models have a rear suspension fork twice redesigned to improve handling and increase the rear cargo space by 5% compared with the previous model. Although both vehicles are larger, boasts of having the best ratio of 0.32 draft air in its segment.

New models in the RX 2010 is the "touch remote controller for the navigation system with hard disk controller, a device on a computer mouse placed in the center console that lies just where the driver generally supports the right hand. The device resembles a joystick and controls the pointer of the navigation screen. A menu, a map and buttons to scroll up and down facilitate the use of the device and of course Lexus did everything possible to minimize the number of screens. The device also can be programmed to measure the level you prefer, allowing drivers to determine the susceptibility of the pointer.