Like the coupe, the Lamborghini Gallardo LP560-4 Spyder loses 44 pounds (20 kg) and wins in its 200 cc V-10 engine, making it a new aluminum 5.2 liter with 552 horsepower and 398 pounds / foot in the pedal. Upgraded engine is mated to the six-speed semiautomatic transmission e.gear rescheduled for Lambo Lamborghini ensures that changes to 40% faster in the "Corsican" sportier. The improvements led to a 4.0 s time to go from 0 to 62 mph (0 to 99.8 km / h) and a maximum speed of 201 mph (323.5 km / h) for the LP560-4 Spyder according to the manufacturer. The Gallardo Spyder was outgoing 10/15 mpg (4.3/6.4 km / l) with the conventional transmission lever and 10/16 mpg (4.3/6.8 km / l) with the semi e.gear, but the LP560-4 is 12 / 20 (5.1/8.5 km / l) and 13/20 (5.6/8.5 km / l) respectively. Impressive numbers for a super car.

Also the brakes LP560-4 Spyder was improved. The brake system is standard vented discs 14.4 inches (37 cm) with eight-piston Brembo clamps front and vented discs of 14.0 inches (36 cm) with four piston back jaws.

Something that has not changed is the design of the Spyder's roof. The Gallardo is a convertible roof. The roof opens or closes in just 20 seconds, a very distinct contrast with the roof afterthought bad reputation Murcielago Spyder. With the roof open the rear glass can be lifted as a wind deflector. Another option is to lower the glass independently maintaining the roof closed. The rollover protection is provided with a pair of spring-actuated bar behind the seats are deployed within 250 milliseconds if needed.  According to Lamborghini, the additional flexibility associated with the lack of a fixed roof is offset by the structural elements of the bodywork has been designed to increase rigidity.